U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1 - 10 of 49 results

Status:
Investigational
Source:
NCT02295592: Not Applicable Interventional Unknown status Hemorrhoids
(2014)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Investigational
Source:
NCT00160862: Phase 1 Interventional Completed Healthy
(2003)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
NCT00090532: Phase 1/Phase 2 Interventional Terminated Age-Related Macular Degeneration
(2004)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Pfizer developed AG-013958, also known as AG-13958 for treatment of age-related macular degeneration (AMD). As a VEGFR tyrosine kinase inhibitor, AG13958 was targeted to FLT/TYK receptor inhibition.
Status:
Investigational
Source:
NCT00003241: Phase 2 Interventional Completed Brain and Central Nervous System Tumors
(1998)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Phenylacetate is the ester of a phenol and acetic acid. It is a metabolite of anticancer drug phenylbutyrate (PB), natural neurotransmitter phenylethylamine. Naturally, it is an odorant found in strawberries, passion fruit, and black tea. Phenylacetate level in urine was used as a marker for the diagnosis of some forms of unipolar major depressive disorders. Phenylacetate is used as a tool substrate to study esterase activity in the blood of patients in clinical studies of the effect of nutritional supplements on paraoxonase-1 levels.